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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AA1 All Species: 13.64
Human Site: T174 Identified Species: 23.08
UniProt: P07900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07900 NP_001017963.2 732 84660 T174 G G S F T V R T D T G E P M G
Chimpanzee Pan troglodytes A5A6K9 733 84754 T174 G G S F T V R T D T G E P M G
Rhesus Macaque Macaca mulatta XP_001098520 724 83571 R177 D H G E P I G R G T K V I L H
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P07901 733 84769 T174 G G S F T V R T D T G E P M G
Rat Rattus norvegicus P82995 733 84796 T174 G G S F T V R T D T G E P M G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512830 733 84847 I174 G G S F T V R I D T G E P I G
Chicken Gallus gallus P11501 728 84041 L173 G G S F T V R L D N G E P L G
Frog Xenopus laevis NP_001085598 729 84174 V175 G G S F T V R V D N S E P L G
Zebra Danio Brachydanio rerio Q90474 725 83300 F173 S F T V K P D F G E S I G R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 Q182 V L Y I K E D Q T D Y L E E S
Honey Bee Apis mellifera XP_395168 718 82735 E173 T V R H D N G E T L G R G T K
Nematode Worm Caenorhab. elegans Q18688 702 80265 I174 E V T R G T K I V M H I K E D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q08277 715 81872 D173 G S F T V T H D T T G E Q L G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P27323 700 80617 K173 E P L G R G T K I T L F L K D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 83 N.A. N.A. 99 99.1 N.A. 95.9 96.1 91.9 85.3 N.A. 77.5 81.2 74.4 N.A.
Protein Similarity: 100 99.7 90.1 N.A. N.A. 99.7 99.7 N.A. 98.2 97.6 96 93.5 N.A. 88.1 90.4 86 N.A.
P-Site Identity: 100 100 6.6 N.A. N.A. 100 100 N.A. 86.6 80 73.3 6.6 N.A. 0 6.6 0 N.A.
P-Site Similarity: 100 100 20 N.A. N.A. 100 100 N.A. 93.3 86.6 80 13.3 N.A. 0 6.6 13.3 N.A.
Percent
Protein Identity: N.A. 68.5 N.A. 70.2 N.A. N.A.
Protein Similarity: N.A. 82.5 N.A. 82.9 N.A. N.A.
P-Site Identity: N.A. 33.3 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 40 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 8 0 15 8 50 8 0 0 0 0 15 % D
% Glu: 15 0 0 8 0 8 0 8 0 8 0 58 8 15 0 % E
% Phe: 0 8 8 50 0 0 0 8 0 0 0 8 0 0 0 % F
% Gly: 58 50 8 8 8 8 15 0 15 0 58 0 15 0 65 % G
% His: 0 8 0 8 0 0 8 0 0 0 8 0 0 0 8 % H
% Ile: 0 0 0 8 0 8 0 15 8 0 0 15 8 8 0 % I
% Lys: 0 0 0 0 15 0 8 8 0 0 8 0 8 8 8 % K
% Leu: 0 8 8 0 0 0 0 8 0 8 8 8 8 29 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 29 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 15 0 0 0 0 0 % N
% Pro: 0 8 0 0 8 8 0 0 0 0 0 0 50 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % Q
% Arg: 0 0 8 8 8 0 50 8 0 0 0 8 0 8 0 % R
% Ser: 8 8 50 0 0 0 0 0 0 0 15 0 0 0 8 % S
% Thr: 8 0 15 8 50 15 8 29 22 58 0 0 0 8 0 % T
% Val: 8 15 0 8 8 50 0 8 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _